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Dynamic characteristics of molten droplets and hot particles falling in liquid pool

Liangxing LI, Weimin MA, Huixiong LI, Tingkuan CHEN,

《能源前沿（英文）》 2010年 第4卷 第2期   页码 246-251 doi: 10.1007/s11708-009-0077-y

摘要： The dynamic characteristics of molten droplets and hot particles at the very beginning of their fall into coolant pools are presented. The falling course of a single droplet or a single hot particle was recorded by a high-speed camera and a curve of velocity . time was obtained. Emphasis was placed on the effects of the droplet’s size and temperature, the coolant’s temperature and properties, and the droplet’s physical properties on the moving behavior. The results for the all cases showed that the velocity of a falling droplet/particle decreased rapidly but rebounded shortly, at the beginning of droplet/particle falling in the coolant. Following such a V-shaped evolution in velocity, the droplet/particle slows down gradually to a comparatively steady velocity. An increase in either coolant temperature or droplet temperature results in a larger velocity variation in the “J-region”, but a smaller deceleration when it moves out of the “J-region”. The elevated volatility of a coolant leads to a steeper deceleration in the “J-region” and beyond. The bigger size of a particle leads to a greater velocity variation in the “J-region” and terminal velocity. A high melting point and thermal conductivity as well as lower heat capacity contribute to dramatic variation in the “J-region” and low terminal velocity.

关键词： dynamic characteristics     molten droplets     high-temperature particles     fuel and coolant interactions    

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Review of characterization and modeling of polymer electrolyte fuel cell catalyst layer: The blessing

Jun HUANG, Zhe LI, Jianbo ZHANG

《能源前沿（英文）》 2017年 第11卷 第3期   页码 334-364 doi: 10.1007/s11708-017-0490-6

摘要： Ionomer impregnation represents a milestone in the evolution of polymer electrolyte fuel cell (PEFC) catalyst layers. Ionomer acts as the binder, facilitates proton transport, and thereby drastically improves catalyst utilization and effectiveness. However, advanced morphological and functional characterizations have revealed that up to 60% of Pt nanoparticles can be trapped in the micropores of carbon support particles. Ionomer clusters and oxygen molecules can hardly enter into micropores, leading to low Pt utilization and effectiveness. Moreover, the ionomer thin-films covering Pt nanoparticles can cause significant mass transport loss especially at high current densities. Ionomer-free ultra-thin catalyst layers (UTCLs) emerge as a promising alternative to reduce Pt loading by improving catalyst utilization and effectiveness, while theoretical issues such as the proton conduction mechanism remain puzzling and practical issues such as the rather narrow operation window remain unsettled. At present, the development of PEFC catalyst layer has come to a crossroads: staying ionomer-impregnated or going ionomer-free. It is always beneficial to look back into the past when coming to a crossroads. This paper addresses the characterization and modeling of both the conventional ionomer-impregnated catalyst layer and the emerging ionomer-free UTCLs, featuring advances in characterizing microscale distributions of Pt particles, ionomer, support particles and unraveling their interactions; advances in fundamental understandings of proton conduction and flooding behaviors in ionomer-free UTCLs; advances in modeling of conventional catalyst layers and especially UTCLs; and discussions on high-impact research topics in characterizing and modeling of catalyst layers.

关键词： polymer electrolyte fuel cell     ultra-thin catalyst layer     electrostatic interactions     characterization and modeling     structure-property-performance relation     water management    

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electrocatalysis: From conventional to single-atomic platinum-based catalysts for proton exchange membrane fuel

《能源前沿（英文）》 doi: 10.1007/s11708-023-0907-3

摘要： Platinum (Pt)-based materials are still the most efficient and practical catalysts to drive the sluggish kinetics of cathodic oxygen reduction reaction (ORR) in proton exchange membrane fuel cells (PEMFCs). However, their catalysis and stability performance still need to be further improved in terms of corrosion of both carbon support and Pt catalyst particles as well as Pt loading reduction. Based on the developed synthetic strategies of alloying/nanostructuring Pt particles and modifying/innovating supports in developing conventional Pt-based catalysts, Pt single-atom catalysts (Pt SACs) as the recently burgeoning hot materials with a potential to achieve the maximum utilization of Pt are comprehensively reviewed in this paper. The design thoughts and synthesis of various isolated, alloyed, and nanoparticle-contained Pt SACs are summarized. The single-atomic Pt coordinating with non-metals and alloying with metals as well as the metal-support interactions of Pt single-atoms with carbon/non-carbon supports are emphasized in terms of the ORR activity and stability of the catalysts. To advance further research and development of Pt SACs for viable implementation in PEMFCs, various technical challenges and several potential research directions are outlined.

关键词： oxygen reduction electrocatalysis     Pt single-atom catalysts     conventional Pt-based catalysts     design thoughts and synthesis     metal-support interactions    

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Latest research progress for LBE coolant reactor of China initiative accelerator driven system project

《能源前沿（英文）》 2021年 第15卷 第4期   页码 810-831 doi: 10.1007/s11708-021-0760-1

摘要： China’s accelerator driven subcritical system (ADS) development has made significant progress during the past decade. With the successful construction and operation of the international prototype of ADS superconducting proton linac, the lead-based critical/subcritical zero-power facility VENUS-II and the comprehensive thermal-hydraulic and material test facilities for LBE (lead bismuth eutectic) coolant, China is playing a pivotal role in advanced steady-state operations toward the next step, the ADS project. The China initiative Accelerator Driven System (CiADS) is the next facility for China’s ADS program, aimed to bridge the gaps between the ADS experiment and the LBE cooled subcritical reactor. The total power of the CiADS will reach 10 MW. The CiADS engineering design was approved by Chinese government in 2018. Since then, the CiADS project has been fully transferred to the construction application stage. The subcritical reactor is an important part of the whole CiADS project. Currently, a pool-type LBE cooled fast reactor is chosen as the subcritical reactor of the CiADS. Physical and thermal experiments and software development for LBE coolant were conducted simultaneously to support the design and construction of the CiADS LBE-cooled subcritical reactor. Therefore, it is necessary to introduce the efforts made in China in the LBE-cooled fast reactor to provide certain supporting data and reference solutions for further design and development for ADS. Thus, the roadmap of China’s ADS, the development process of the CiADS, the important design of the current CiADS subcritical reactor, and the efforts to build the LBE-cooled fast reactor are presented.

关键词： LBE (lead bismuth eutectic) coolant reactor     China initiative Accelerator Driven System (CiADS) project     research progress    

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Pt–C interactions in carbon-supported Pt-based electrocatalysts

《化学科学与工程前沿（英文）》 2023年 第17卷 第11期   页码 1677-1697 doi: 10.1007/s11705-023-2300-5

摘要： Carbon-supported Pt-based materials are highly promising electrocatalysts. The carbon support plays an important role in the Pt-based catalysts by remarkably influencing the growth, particle size, morphology, dispersion, electronic structure, physiochemical property and function of Pt. This review summarizes recent progress made in the development of carbon-supported Pt-based catalysts, with special emphasis being given to how activity and stability enhancements are related to Pt–C interactions in various carbon supports, including porous carbon, heteroatom doped carbon, carbon-based binary support, and their corresponding electrocatalytic applications. Finally, the current challenges and future prospects in the development of carbon-supported Pt-based catalysts are discussed.

关键词： Pt–C interactions     Pt-based materials     carbon support     electrocatalysis    

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Liquid metal as energy transportation medium or coolant under harsh environment with temperature below

Yunxia GAO, Lei WANG, Haiyan LI, Jing LIU

《能源前沿（英文）》 2014年 第8卷 第1期   页码 49-61 doi: 10.1007/s11708-013-0285-3

摘要： The current highly integrated electronics and energy systems are raising a growing demand for more sophisticated thermal management in harsh environments such as in space or some other cryogenic environment. Recently, it was found that room temperature liquid metals (RTLM) such as gallium or its alloys could significantly reduce the electronics temperature compared with the conventional coolant, like water, oil or more organic fluid. However, most of the works were focused on RTLM which may subject to freeze under low temperature. So far, a systematic interpretation on the preparation and thermal properties of liquid metals under low temperature (here defined as lower than 0°C) has not yet been available and related applications in cryogenic field have been scarce. In this paper, to promote the research along this important direction and to overcome the deficiency of RTLM, a comprehensive evaluation was proposed on the concept of liquid metal with a low melting point below zero centigrade, such as mercury, alkali metal and more additional alloy candidates. With many unique virtues, such liquid metal coolants are expected to open a new technical frontier for heat transfer enhancement, especially in low temperature engineering. Some innovative ways for making low melting temperature liquid metal were outlined to provide a clear theoretical guideline and perform further experiments to discover new materials. Further, a few promising applied situations where low melting temperature liquid metals could play irreplaceable roles were detailed. Finally, some main factors for optimization of low temperature coolant were summarized. Overall, with their evident merits to meet various critical requirements in modern advanced energy and power industries, liquid metals with a low melting temperature below zero centigrade are expected to be the next-generation high-performance heat transfer medium in thermal managements, especially in harsh environment in space.

关键词： liquid metal     cryogenics     low melting point     thermal management     aircraft     liquid cooling     space exploration    

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Analysis of a 1 kW organic Rankine cycle using a scroll expander for engine coolant and exhaust heat

Yiji LU, Anthony Paul ROSKILLY, Long JIANG, Longfei CHEN, Xiaoli YU

《能源前沿（英文）》 2017年 第11卷 第4期   页码 527-534 doi: 10.1007/s11708-017-0516-0

摘要： The development of engine waste heat recovery technologies attracts ever increasing interests due to the rising strict policy requirements and environmental concerns. This paper presented the study of engine coolant and exhaust heat recovery using organic Rankine cycle (ORC). Eight working fluids were selected to evaluate and compare the performance of the integrated waste heat recovery system. Rather than the conventional engine ORC system mainly focusing on the utilization of exhaust energy, this work proposed to fully use the engine coolant energy by changing the designed parameters of the ORC system. The case study selected a small engine as the heat source to drive the ORC system using a scroll expander for power production. The evaluation results suggest that under the engine rated condition, the solution to fully recover the engine coolant energy can achieve a higher power generation performance than that of the conventional engine ORC system. The results suggest that adding a recuperator to the ORC system can potentially improve the system performance when the working fluids are dry and the overall dumped heat demand of the system can be reduced by 12% under optimal conditions. When the ORC evaporating and condensing temperature are respectively set at 85°C and 30°C, the integrated engine waste heat recovery system can improve the overall system efficiency by 9.3% with R600, R600a or -Pentane as the working fluid.

关键词： organic Rankine cycle     scroll expander     coolant and exhaust recovery     internal combustion engine    

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Responses of microbial interactions to elevated salinity in activated sludge microbial community

《环境科学与工程前沿（英文）》 2023年 第17卷 第5期 doi: 10.1007/s11783-023-1660-x

摘要：

● Salinity led to the elevation of NAR over 99.72%.

关键词： Elevated salinity     Activated sludge system     Pollution removal     Microbial interactions     Competitive relationship    

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Water, energy and food interactions–Challenges and opportunities

Gustaf OLSSON

《环境科学与工程前沿（英文）》 2013年 第7卷 第5期   页码 787-793 doi: 10.1007/s11783-013-0526-z

摘要： Water and energy are inextricably linked, and as a consequence both have to be addressed together. This is called the water-energy nexus. When access to either is limited, it becomes obvious that it is necessary to consider their interdependence. Population growth, climate change, urbanization, increasing living standards and food consumption will require an integrated approach where food, water and energy security are considered together. In this paper we examine water, energy and food security and their couplings. The nexus also creates conflicts between water use, energy extraction and generation as well as food production. Some of these conflicts are illustrated. It is argued that there is an urgent need for integrated planning and operation. Not only will better technology be needed, but also better integration of policies, organizations and political decisions.

关键词： water security     energy security     food security     water-energy nexus     water conflicts    

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Microfluidics for cell-cell interactions: A review

Rui Li,Xuefei Lv,Xingjian Zhang,Omer Saeed,Yulin Deng

《化学科学与工程前沿（英文）》 2016年 第10卷 第1期   页码 90-98 doi: 10.1007/s11705-015-1550-2

摘要： Microfluidic chip has been applied in various biological fields owing to its low-consumption of reagents, high throughput, fluidic controllability and integrity. The well-designed microscale intermediary is also ideal for the study of cell biology. Particularly, microfluidic chip is helpful for better understanding cell-cell interactions. A general survey of recent publications would help to generalize the designs of the co-culture chips with different features. With ingenious and combinational utilization, the chips facilitate the implementation of some special co-culture models that are highly concerned in a different spatial and temporal way.

关键词： microfluidic chip     co-culture     cell-cell interactions     review    

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SUSTAINABLE CROP AND PASTURE SYSTEMS: FROM ABOVE- AND BELOWGROUND INTERACTIONS TO ECOSYSTEM MULTIFUNCTIONALITY

《农业科学与工程前沿（英文）》 2022年 第9卷 第2期   页码 167-169 doi: 10.15302/J-FASE-2022446

摘要：

Intensive agriculture, characterized by strong reliance on excessive amount of external agrochemical inputs in simplified cropping systems has contributed successfully to feeding an increasing number of humans, but at the expense of severe resource and environmental costs. Consequently, the Earth is facing multifaceted challenges, including increasing food demand both in quantity and quality, global warming associated with extreme weather events, soil degradation and depletion of natural resources. To address some of these challenges, we have developed this Special Issue on Sustainable Crop and Pasture Systems for Frontiers of Agricultural Sciences and Engineering (FASE). The issue addresses the research frontiers of two main themes: (1) aboveground-belowground ecological and physiological mechanisms, processes and ecosystem functions; and (2) the synergies and trade-offs between multiple ecosystem services in sustainable crop and pasture systems. There are 10 articles in this Special Issue including review and research articles with contributions from Australia, China, France, the Netherlands, and the UK. The contributors are all highly-regarded scientists devoted to studies on mechanisms and applications of sustainable crop and pasture systems.

Sustainable crop and pasture systems have a potential to enhance the synergies in multiple ecosystem services, consisting of higher food production, lower environmental impacts and climate change mitigation. To innovate sustainable cropping systems requires deeper and comprehensive understanding of mechanisms underlying above- and belowground interactions. Hans Lambers and Wen-Feng Cong emphasized the importance of diversifying crop species or genotypes with complementary or facilitative functional traits. This will mediate key ecosystem processes related to water, carbon and nutrients, contributing to higher resource-use efficiency and enhancing synergies in ecosystem services ( https://doi.org/10.15302/J-FASE-2022444). Root functional traits such as root exudates are pivotal in nutrient mobilization, either directly mobilizing plant nutrients in the soil or indirectly so via modifications of the soil microbiome. Cathryn A. O'Sullivan and coworkers reported a novel role of root exudates from canola in inhibiting nitrification in soils. They found that these root exudates (called biological nitrogen (N) inhibitors) can significantly reduce nitrification rates of both Nitrosospira multiformis cultures and native nitrifying communities in soil. This would reduce nitrate losses, but increase plant N uptake and microbial N immobilization, subsequently benefiting the following cereal crops through mineralization of this organic N pool ( https://doi.org/10.15302/J-FASE-2021421). Jonathan Storkey and Andrew J. Macdonald used the longest-lasting grassland biodiversity experiment in the world to examine the relationships between plant functional traits and ecosystem services. They reported a strong trade-off between plots with high productivity, N inputs and soil organic carbon and plots with a large number of plant species with contrasting nutrient-acquisition strategies. An increasing proportion of forbs with greater longevity and lower leaf dry matter content can partly mitigate the trade-offs between plant diversity and productivity ( https://doi.org/10.15302/J-FASE-2021438).

John A. Raven further explored synergies or trade-offs of ecosystem services regulated by above- and belowground interactions, mainly functioning through energy, material and information pathways. Solar energy is the key driver for photosynthesis and transpiration, modulating the flow of water and nutrients in soils moving aboveground and the flow of carbohydrates feeding belowground biota. Information transfer can be through hydraulic, electrical and chemical signaling, regulating plant development, abiotic and biotic damage and resource excess and limitation ( https://doi.org/10.15302/J-FASE-2021433).

Timothy S. George and coauthors highlighted the importance of harnessing biodiversity principles and physiological mechanisms in diversified cropping systems to achieve agricultural sustainability. They demonstrate that crop diversification combined with optimized management such as minimum tillage and reduced fertilizer inputs can improve soil quality, promoting soil biotic activities and associated functions. This will reduce the reliance on agrochemical inputs and environmental impacts, and increase climatic resilience ( https://doi.org/10.15302/J-FASE-2021437). Ruqiang Zhang and coworkers applied the One Health concept to design healthy dairy farms. They employed a wide range of soil and plant diversity measures such as intercropping, crop rotation and flower strips at both field and landscape scales to reduce the inputs of fertilizers, pesticides as well as soil compaction caused by heavy machines. The biodiversity-based solutions can help dairy farmers maintain a healthy eco-environment, while producing high-quality milk ( https://doi.org/10.15302/J-FASE-2022445). Emily C. Cooledge and her colleagues show that introducing multispecies leys with perennial legumes and other forbs into arable rotations will achieve multiple ecosystem benefits. This occurs mainly in three ways—return of livestock manure, permanent soil cover and less disturbance of soil—which promote soil food web interactions and soil aggregate stability, subsequently sequestering more carbon in soils ( https://doi.org/10.15302/J-FASE-2021439). Ting Luo and coauthors used the sugarcane cropping system in China as an example and analyzed the current challenges and problems and proposed a wide range of crop, soil and input management practices such as crop rotation, strategic tillage and optimized nutrient management to achieve sustainable sugarcane cropping systems ( https://doi.org/10.15302/J-FASE-2022442).

Focusing on the multi-objective assessment of different cropping systems, Léa Kervroëdan and coworkers assessed the agronomic and environmental impacts of food, feed and mixed (food, feed and biogas) cropping systems. They found that mixed cropping systems had a greater potential of bioenergy production and agronomic performance, but also higher greenhouse gas emissions. This warrants long-term examination of whether short-term higher greenhouse gas emissions can be offset by long-term soil carbon sequestration in this system ( https://doi.org/10.15302/J-FASE-2021435). Jeroen C. J. Groot and Xiaolin Yang applied a new mathematical approach of evolutionary multi-objective optimization to 30 cropping systems practiced on the North China Plain with the aim of overcoming the trade-offs between revenues, energy and nutrient supply and groundwater depletion at a regional level. This approach allows national or regional policymakers to plan growing area of certain sustainable cropping systems ( https://doi.org/10.15302/J-FASE-2021434).

As the Guest Editors, we thank all authors and reviewers for their valuable contributions to this Special Issue on Sustainable Crop and Pasture Systems. We also thank the FASE editorial team for their professional support.

Dr. Wen-Feng Cong, Associate Professor at College of Resource and Environmental Sciences, China Agricultural University. He obtained his PhD at Wageningen University in the Netherlands and conducted postdoctoral research at Aarhus University in Denmark. His research focuses on understanding the mechanisms underlying the positive effects of crop, genotype and cropping system diversity on soil carbon sequestration and soil phosphorus utilization, and applying the ecological mechanisms to design sustainable diversified cropping systems. He is author of over 30 papers in peer-reviewed scientific journals, including Trends in Plant Science, Trends in Ecology & Evolution, and Global Change Biology. He is leading or participating in sustainable cropping systems related projects funded by the National Natural Science Foundation of China and the Chinese Academy of Engineering. He is acting as a member of the editorial board of Frontiers in Agronomyand Frontiers in Soil Science.

Dr. Hans Lambers, Emeritus Professor at the University of Western Australia and Distinguished Professor at College of Resource and Environmental Sciences, China Agricultural University. He obtained his PhD at the University of Groningen in the Netherlands and conducted postdoctoral research in Australia and the Netherlands, before taking up a position of Professor of Plant Ecophysiology at Utrecht University in the Netherlands and then Professor of Plant Biology and Ecology at the University of Western Australia in Australia. His research focuses on understanding plant–soil interactions and plant nutrition, with an emphasis on Australian plants and crop legumes. He is author of over 550 papers in peer-reviewed scientific journals, including Annual Review of Plant Biology,Trends in Plant Science, Trends in Ecology & Evolution, New Phytologist, Plant and Soil,Global Change Biology, andNature Plants. He is leading or participating in projects on plant nutrition funded by the Australian Research Council. He is the lead author of an influential textbook, Plant Physiological Ecology (1998, 2008, and 2019), Editor in Chief of Plant and Soil(1992–present), and Associate Editor in Chief ofFrontiers of Agricultural Sciences and Engineering

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THE 4C APPROACH AS A WAY TO UNDERSTAND SPECIES INTERACTIONS DETERMINING INTERCROPPING PRODUCTIVITY

《农业科学与工程前沿（英文）》 2021年 第8卷 第3期   页码 387-399 doi: 10.15302/J-FASE-2021414

摘要：

Modern agriculture needs to develop transition pathways toward agroecological, resilient and sustainable farming systems. One key pathway for such agroecological intensification is the diversification of cropping systems using intercropping and notably cereal-grain legume mixtures. Such mixtures or intercrops have the potential to increase and stabilize yields and improve cereal grain protein concentration in comparison to sole crops. Species mixtures are complex and the 4C approach is both a pedagogical and scientific way to represent the combination of four joint effects of Competition, Complementarity, Cooperation, and Compensation as processes or effects occurring simultaneously and dynamically between species over the whole cropping cycle. Competition is when plants have fairly similar requirements for abiotic resources in space and time, the result of all processes that occur when one species has a greater ability to use limiting resources (e.g., nutrients, water, space, light) than others. Complementarity is when plants grown together have different requirements for abiotic resources in space, time or form. Cooperation is when the modification of the environment by one species is beneficial to the other(s). Compensation is when the failure of one species is compensated by the other(s) because they differ in their sensitivity to abiotic stress. The 4C approach allows to assess the performance of arable intercropping versus classical sole cropping through understanding the use of abiotic resources.

 

关键词： compensation     competition     complementarity     cooperation     interspecific interactions     land equivalent ratio     light     nutrients     species mixtures     water    

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Biopolymer-stabilized emulsions on the basis of interactions between β -lactoglobulin and ι -carrageenan

Qiaomei RU, Younghee CHO, Qingrong HUANG,

《化学科学与工程前沿（英文）》 2009年 第3卷 第4期   页码 399-406 doi: 10.1007/s11705-009-0253-y

摘要： -Carrageenan and -lactoglobulin (-lg) stabilized oil-in-water (O/W) emulsions, which can be used for the oral administration of bioactive but environmentally sensitive ingredients, have been successfully prepared. The effects of protein/polysaccharide ratios, total biopolymer concentration, environmental stress (thermal processing and sonication), and pH on the complex formation between -carrageenan and -lactoglobulin have been investigated. We found that -lactoglobulin and-carrageenan stabilized emulsions can be formed at pH values of 6.0, 4.0, and 3.4. However, the microstructures of emulsions stabilized by -lactoglobulin and -carrageenan was identified by optical microscopy, and it indicated that the emulsion prepared at pH 6.0 flocculated more extensively, while its hydrodynamic radius was much bigger than those prepared at pH 4.0 and 3.4. Regarding rheological properties, the emulsion of pH 6.0 showed a more solid-like behavior but with a lower viscosity than those of pH 4.0 and 3.4. The optimum concentration ranges for -lg and-carrageenan to form stable emulsions at pH 4.0 and 3.4 were 0.3wt-%―0.6wt-% and 0.4wt-%―0.7wt-%, respectively.
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Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction

Hong LI,Ziding ZHANG

《农业科学与工程前沿（英文）》 2016年 第3卷 第2期   页码 102-112 doi: 10.15302/J-FASE-2016100

摘要： Plants are frequently affected by pathogen infections. To effectively defend against such infections, two major modes of innate immunity have evolved in plants; pathogen-associated molecular pattern-triggered immunity and effector-triggered immunity. Although the molecular components as well as the corresponding pathways involved in these two processes have been identified, many aspects of the molecular mechanisms of the plant immune system remain elusive. Recently, the rapid development of omics techniques (e.g., genomics, proteomics and transcriptomics) has provided a great opportunity to explore plant–pathogen interactions from a systems perspective and studies on protein–protein interactions (PPIs) between plants and pathogens have been carried out and characterized at the network level. In this review, we introduce experimental and computational identification methods of PPIs, popular PPI network analysis approaches, and existing bioinformatics resources/tools related to PPIs. Then, we focus on reviewing the progress in genome-wide PPI networks related to plant–pathogen interactions, including pathogen-centric PPI networks, plant-centric PPI networks and interspecies PPI networks between plants and pathogens. We anticipate genome-wide PPI network analysis will provide a clearer understanding of plant–pathogen interactions and will offer some new opportunities for crop protection and improvement.

关键词： plant–pathogen interactions     systems biology     omics     plant immunity     protein–protein interaction     network    

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Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy

《医学前沿（英文）》 2022年 第16卷 第3期   页码 307-321 doi: 10.1007/s11684-022-0927-0

摘要： The discovery of immune checkpoint inhibitors, such as PD-1/PD-L1 and CTLA-4, has played an important role in the development of cancer immunotherapy. However, immune-related adverse events often occur because of the enhanced immune response enabled by these agents. Antibiotics are widely applied in clinical treatment, and they are inevitably used in combination with immune checkpoint inhibitors. Clinical practice has revealed that antibiotics can weaken the therapeutic response to immune checkpoint inhibitors. Studies have shown that the gut microbiota is essential for the interaction between immune checkpoint inhibitors and antibiotics, although the exact mechanisms remain unclear. This review focuses on the interactions between immune checkpoint inhibitors and antibiotics, with an in-depth discussion about the mechanisms and therapeutic potential of modulating gut microbiota, as well as other new combination strategies.

关键词： tumor immunotherapy     immune checkpoint inhibitor     antibiotics     gut microbiota     drug–drug interaction    

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标题 作者 时间 类型 操作

Dynamic characteristics of molten droplets and hot particles falling in liquid pool

Liangxing LI, Weimin MA, Huixiong LI, Tingkuan CHEN,

期刊论文

Review of characterization and modeling of polymer electrolyte fuel cell catalyst layer: The blessing

Jun HUANG, Zhe LI, Jianbo ZHANG

期刊论文

electrocatalysis: From conventional to single-atomic platinum-based catalysts for proton exchange membrane fuel

期刊论文

Latest research progress for LBE coolant reactor of China initiative accelerator driven system project

期刊论文

Pt–C interactions in carbon-supported Pt-based electrocatalysts

期刊论文

Liquid metal as energy transportation medium or coolant under harsh environment with temperature below

Yunxia GAO, Lei WANG, Haiyan LI, Jing LIU

期刊论文

Analysis of a 1 kW organic Rankine cycle using a scroll expander for engine coolant and exhaust heat

Yiji LU, Anthony Paul ROSKILLY, Long JIANG, Longfei CHEN, Xiaoli YU

期刊论文

Responses of microbial interactions to elevated salinity in activated sludge microbial community

期刊论文

Water, energy and food interactions–Challenges and opportunities

Gustaf OLSSON

期刊论文

Microfluidics for cell-cell interactions: A review

Rui Li,Xuefei Lv,Xingjian Zhang,Omer Saeed,Yulin Deng

期刊论文

SUSTAINABLE CROP AND PASTURE SYSTEMS: FROM ABOVE- AND BELOWGROUND INTERACTIONS TO ECOSYSTEM MULTIFUNCTIONALITY

期刊论文

THE 4C APPROACH AS A WAY TO UNDERSTAND SPECIES INTERACTIONS DETERMINING INTERCROPPING PRODUCTIVITY

期刊论文

Biopolymer-stabilized emulsions on the basis of interactions between β -lactoglobulin and ι -carrageenan

Qiaomei RU, Younghee CHO, Qingrong HUANG,

期刊论文

Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction

Hong LI,Ziding ZHANG

期刊论文

Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy

期刊论文